In the citrate cycle, a high concentration of NADH would result in
A) activation of citrate synthase.
B) inhibition of $\alpha$-ketoglutarate dehydrogenase.
C) inhibition of fumarase.
D) activation of $\alpha$-ketoglutarate dehydrogenase.

Question

Quizplus · Accepted Answer

Inhibition of F1F1F1S1F1F1F10-ketoglutarate dehydrogenase. High concentration of NADH signals that there is already enough energy in the cell and the citrate cycle needs to slow down to avoid excessive buildup of NADH. Therefore, NADH acts as a negative feedback inhibitor of the key regulatory enzyme F1F1F1S1F1F1F10-ketoglutarate dehydrogenase, which controls the entry of acetyl-CoA into the citrate cycle.

In the Citrate Cycle, a High Concentration of NADH Would α\alphaα

In the Citrate Cycle, a High Concentration of NADH Would $\alpha$