What property defines most ligands for intracellular receptors?
A)They are lipid-soluble
B)They are hydrophilic
C)They are molecules that can perform significant hydrogen bonding interactions with water
D)They are large molecules

Question

Quizplus · Accepted Answer

Most ligands for intracellular receptors are lipid-soluble, allowing them to cross the hydrophobic cell membrane and enter the cell. Hydrophilic molecules cannot cross the membrane and are therefore unable to interact with intracellular receptors. Molecules that can perform significant hydrogen bonding interactions with water, such as hydrophilic molecules, are typically not able to interact with the hydrophobic interior of the cell membrane or bind to intracellular receptors. Large molecules may be unable to cross the cell membrane or may be excluded from binding to the receptor due to steric hindrance.

What Property Defines Most Ligands for Intracellular Receptors