Which of the following reactions will provide the best yield of ether by the Williamson ether synthesis?
A)Bromobenzene and sodium methoxide
B)Phenol and sodium methoxide
C)Bromobenzene and bromomethane
D)Sodium phenoxide and bromomethane

Question

Quizplus · Accepted Answer

The best yield of ether will be obtained with the reaction between sodium phenoxide and bromomethane. This is because the reaction involves the use of an unhindered alkylating agent (bromomethane) on a hindered nucleophile (phenoxide ion), following the principle of Williamson ether synthesis. This results in the formation of a stable ether product with high yield.

Which of the Following Reactions Will Provide the Best Yield