What are the three steps in the malonic ester synthesis?
A)Deprotonation,alkylation,hydrolysis/decarboxylation
B)Hydrogenation,alkylation,deprotonation
C)Alkylation,hydrolysis/decarboxylation.hydrogenation
D)Hydrolysis/decarboxylation,deprotonation,alkylation

Question

Quizplus · Accepted Answer

The three steps in the malonic ester synthesis are deprotonation of the acidic α-hydrogen with a strong base (such as sodium ethoxide), alkylation with an appropriate alkylating agent (such as an alkyl halide), and finally hydrolysis and decarboxylation using acid (such as HCl) or base (such as NaOH). Option A contains the correct order and steps involved in the malonic ester synthesis.

What Are the Three Steps in the Malonic Ester Synthesis