If a Claisen condensation reaction is run using methyl propanoate as the reactant,NaOCH₃ is the ideal base.Why is it important to use NaOCH₃ and not NaOCH₂CH₃? A)NaOCH₃ is a stronger base than NaOCH₂CH₃,and this reaction requires a stronger base. B)NaOCH₃ is a weaker base than NaOCH₂CH₃,and this reaction requires a weaker base. C)Transesterfication can occur when esters react,and this transesterfication would result in a mixture of products. D)NaOCH₃ is more soluble than NaOCH₂CH₃ in organic solvents,and this reaction requires a full equivalent of base to proceed.A full equivalent of NaOCH₂CH₃ would not dissolve,so the reaction would not proceed.

Question

Quizplus · Accepted Answer

Using NaOCH₂CH₃ as the base could result in transesterification, which would lead to a mixture of products. The Claisen condensation reaction requires a specific starting material, and introducing side reactions like transesterification can complicate the reaction and result in a less pure product. Therefore, it is important to use NaOCH₃ to avoid this issue. Option A and B are incorrect because the strength of the base is not the determining factor in this case. Option D is incorrect because the solubility of the base is not relevant in this situation.

If a Claisen Condensation Reaction Is Run Using Methyl Propanoate