Which Is True Regarding Pyrogens

Which is true regarding pyrogens?

A) They can reset the temperature-regulating center in the hypothalamus and raise the body temperature.
B) They break down tissue by autolysis, releasing digestive enzymes that first destroy the injured cells and then attack surrounding tissues.
C) They act only within one tissue.
D) They are particularly sensitive to chemicals released by other body cells or by pathogens.
E) They make capillaries more permeable and speed up blood flow through the area within the damaged tissue.