In hemoglobin C disease, how does the mutation affect the hemoglobin molecule?
A) It cannot carry oxygen.
B) It has decreased hemoglobin solubility.
C) It is unstable.
D) It has increased oxygen affinity.

Question

Quizplus · Accepted Answer

The mutation in hemoglobin C disease results in a substitution of glutamic acid with lysine in the beta chain of hemoglobin. This reduces the solubility of hemoglobin C and causes it to form abnormal clumps in red blood cells, which can lead to anemia and organ damage. However, hemoglobin C is still able to carry oxygen.

In Hemoglobin C Disease, How Does the Mutation Affect the Hemoglobin