A patient presents with a leukocyte count of 120 × 10⁹/L and splenomegaly. The blood smear reveals a shift to the left with promyelocytes and blasts. The platelets are increased, and the LAP is decreased. Which condition is associated with these results? A) Bacterial infection B) Reactive chronic neutrophilia C) Leukemoid reaction D) CML

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Quizplus · Accepted Answer

The combination of increased leukocyte count, left shift with immature cells including blasts and promyelocytes, splenomegaly, increased platelets, and decreased LAP score are all indicative of chronic myeloid leukemia (CML). Bacterial infections and reactive chronic neutrophilia may cause an increase in leukocytes, but they do not typically result in the presence of blast cells or other immature cells. Leukemoid reactions can also result in a left shift and increased leukocyte count, but they are typically not associated with splenomegaly, and the LAP score is typically normal or increased.

A Patient Presents with a Leukocyte Count of 120 ×