Which of the Following Statements Is True About Hemolytic Disease

Which of the following statements is true about hemolytic disease of the newborn?

A) Hemolytic disease of the newborn occurs when the father is Rh^- and the mother is Rh⁺.
B) Hemolytic disease of the newborn would be a problem any time the mother is Rh^-, regardless of the father's blood type.
C) Hemolytic disease of the newborn occurs when a Rh^- mother and a Rh⁺ father produce an Rh⁺ child.
D) If a mother has a higher threshold for rejecting foreign tissues there is a higher chance of the baby having hemolytic newborn disease.
E) The problem is complicated because the disease is dependent on both Rh factor and ABO blood groups.