Due to the wobble hypothesis,which position in the codon,if changed to a different nucleotide,would be least likely to cause a change in the amino acid encoded?
A)second nucleotide of the codon
B)first nucleotide of the codon
C)third nucleotide of the codon
D)any nucleotide of the codon.
E)Either the first or second nucleotide of the codon.

Question

Quizplus · Accepted Answer

The wobble hypothesis states that the first two nucleotides in a codon form Watson-Crick base pairs with the corresponding nucleotides in the anticodon of the tRNA, while the third nucleotide may form a non-traditional or "wobble" base pair. Because of this, changing the third nucleotide in a codon is least likely to result in a change in the amino acid encoded, as long as the new nucleotide also forms a wobble base pair with the corresponding nucleotide in the tRNA anticodon. Therefore, choice C is the correct answer.

Due to the Wobble Hypothesis,which Position in the Codon,if Changed