The hydrolysis of phosphoenolpyruvate proceeds with a $\Delta$G'° of about -62 kJ/mol. The greatest contributing factors to this reaction are the destabilization of the reactants by electostatic repulsion and stabilization of the product pyruvate by:
A) electrostatic attraction.
B) ionization.
C) polarization.
D) resonance.
E) tautomerization.

Question

Quizplus · Accepted Answer

The stabilization of the product pyruvate is greatly enhanced by tautomerization, which is the conversion of the enol form to the more stable keto form. This contributes significantly to the large negative free energy change.

The Hydrolysis of Phosphoenolpyruvate Proceeds with A Δ\DeltaΔ G'° of About -62 KJ/mol

The Hydrolysis of Phosphoenolpyruvate Proceeds with A $\Delta$ G'° of About -62 KJ/mol