Azaserine is a structural analog of glutamine.It is a competitive inhibitor of many enzymes that use glutamine as substrates.Name)three biosynthetic products whose synthesis you would expect to be inhibited by azaserine.Do you think that eating azaserine would be immediately fatal? Why or why not?
Diagram the biosynthetic pathway from UMP to dTTP.Use abbreviations (e.g. ,UMP),not complete structures,and indicate where any co-substrates participate.
Show the reaction catalyzed by thymidylate synthase and explain with a simple diagram how the chemotherapeutic agents fluorouracil and methotrexate inhibit the synthesis of dTMP.
Explain how lack of adenosine deaminase leads to a 100-fold increase in dATP,yet also causes a deficiency in dNTPs required for replication of T-cells and B-cells required for a functioning immune system.