A key problem of time series is history: certain events or factors that have an impact on the independent variable-dependent variable relationship might unexpectedly occur while the experiment is in progress.

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This is true, as time series data is collected over a period of time and various events or factors may impact the relationship between the independent and dependent variables in unpredictable ways. This can make it challenging to analyze and make predictions based on the data.

A Key Problem of Time Series Is History: Certain Events