Which of the following best explains how the phenomenon of "tolerance" develops with use of psychoactive drugs over time?
A)Psychoactive drugs can alter blood flow to the brain.
B)Psychoactive drugs often produce euphoria.
C)Psychoactive drugs can cross the blood-brain barrier.
D)Psychoactive drugs can inhibit production of endogenous neurotransmitters.
E)Psychoactive drugs can up-regulate receptors for endogenous neurotransmitters.

Question

Quizplus · Accepted Answer

ETolerance develops when the body adjusts to the presence of the drug, often through physiological changes. One such change is the inhibition of the production of endogenous (naturally occurring) neurotransmitters (D), as the body compensates for the artificial increase in neurotransmitter activity caused by the drug. Another change can be the up-regulation (increase in the number) of receptors for these neurotransmitters (E), as the body attempts to maintain normal function despite the presence of the drug.

Which of the Following Best Explains How the Phenomenon of "Tolerance