Which of the Following Is True Regarding Pituitary Growth Hormone

Which of the following is true regarding pituitary growth hormone (GH) ?

A) The liver produces a factor that mediates the metabolic actions of GH.
B) GH stimulates insulin-like growth factor-1 (IGF-1) production by the liver and by many other cells.
C) GH increases the sensitivity of tissues to the action of insulin.
D) GH exerts negative feedback on its own production by inhibiting the hypothalamic secretion of somatostatin.
E) IGF-1 stimulates the secretion of GH by anterior pituitary gland cells.