Glucose cannot be synthesized from fatty acids because the reaction converting pyruvic acid to acetyl coenzyme A is not reversible.

Question

Quizplus · Accepted Answer

The reaction converting pyruvic acid to acetyl coenzyme A is irreversible, meaning that once pyruvic acid is converted to acetyl CoA, it cannot be converted back into pyruvic acid or glucose. Therefore, fatty acids cannot be converted into glucose, as glucose cannot be synthesized from acetyl CoA.

Glucose Cannot Be Synthesized from Fatty Acids Because the Reaction