The shape of a ligand and the shape of its binding site influence both the specificity and the affinity of binding.

Question

Quizplus · Accepted Answer

The statement is true. The specific and strong binding between a ligand and its binding site is dependent on the complementary shapes of both the ligand and the binding site. This is why certain ligands can only bind to certain proteins or receptors, and why even small changes in the shape of the binding site can affect the strength of binding.

The Shape of a Ligand and the Shape of Its