What is "allosteric modulation"?
A) regulation of physiological functions by the sympathetic division of the autonomic nervous system
B) modification of the functional state of a protein by temperature or pH
C) the change in the shape and functional state of a protein that occurs when a ligand binds to a regulatory site
D) the fact that all binding sites on a protein must be occupied to have a biological effect
E) the ability of a single ligand-binding site to bind to molecularly similar ligands

Question

Quizplus · Accepted Answer

Allosteric modulation refers to the change in the functional state of a protein when a ligand binds to a regulatory site, causing a change in the protein's shape and function. This is different from other forms of regulation, such as regulation by the sympathetic division of the autonomic nervous system (A), which involves the release of neurotransmitters, or modification of a protein's functional state by temperature or pH (B). The fact that all binding sites on a protein must be occupied to have a biological effect (D) is known as the all-or-none principle, and the ability of a single ligand-binding site to bind to molecularly similar ligands (E) is known as selectivity.

What Is "Allosteric Modulation