For Diels-Alder cycloaddition reactions to take place most rapidly and in highest yield the dienophile must:
A)be substituted with electron-withdrawing groups
B)be able to adopt an s-trans conformation
C)be substituted with electron-donating groups
D)be able to adopt an s-cis conformation

Question

Quizplus · Accepted Answer

Electron-withdrawing groups on the dienophile make it more electrophilic, facilitating the Diels-Alder reaction with the electron-rich diene.

For Diels-Alder Cycloaddition Reactions to Take Place Most Rapidly and in Highest