During exercise,skeletal muscle can release local factors,such as adenosine,which can relax neighboring vascular smooth muscle and thus promote vasodilation in the exercising muscle.The mechanism by which adenosine promotes relaxation of smooth muscle typically involves: A)Inhibition of K⁺ channels in the vascular smooth muscle. B)Stimulation of InsP3 production in the vascular smooth muscle. C)Stimulation of release of endothelin from adjacent endothelial cells. D)Stimulation of cAMP production in the vascular smooth muscle. E)Activation of voltage-gated Ca⁺⁺ channels in the vascular smooth muscle.

Question

Quizplus · Accepted Answer

Adenosine typically activates adenosine receptors in vascular smooth muscle, which in turn stimulate the production of cAMP. This leads to activation of protein kinase A (PKA), which phosphorylates and inhibits myosin light chain kinase (MLCK), resulting in relaxation of the smooth muscle and vasodilation.

During Exercise,skeletal Muscle Can Release Local Factors,such as Adenosine,which Can