Which compound would react most rapidly with sodium methoxide and heat?
A) pyridine
B) 2-chloropyridine
C) 3-chloropyridine
D) 4-chloropyridine

Question

Quizplus · Accepted Answer

The presence of a halogen on the pyridine ring increases the reactivity towards nucleophilic substitution reactions. Among the given options, 2-chloropyridine has the chlorine atom in closest proximity to the methoxide nucleophile, making it the most reactive towards the reaction.

Which Compound Would React Most Rapidly with Sodium Methoxide and Heat