With respect to noncoding RNA (ncRNA) , which, if any, of the following statements, is false?
A) Many long noncoding RNAs work in epigenetic regulation of gene expression.
B) Most regulatory long ncRNAs work as trans-acting regulators.
C) HOTAIR RNA is produced by a gene in the HOXC homeobox gene cluster at 12q13 but can regulate multiple genes within the HOXD gene cluster on chromosome 2.
D) HOTAIR RNA works as a scaffold that binds specific protein regulators at its two ends.

Question

Quizplus · Accepted Answer

Most of the regulatory long ncRNAs work as cis-acting regulators, not trans-acting regulators. Trans-acting regulators act on genes located on different chromosomes, whereas cis-acting regulators act on genes located on the same chromosome as the gene that produced the ncRNA.

With Respect to Noncoding RNA (NcRNA) , Which, If Any