With respect to microRNAs, which, if any, of the following statements, is false?
A) A microRNA normally works by binding to perfectly complementary sequences within an RNA transcript, usually an mRNA.
B) Like the great majority of mRNAs an miRNA is usually produced as a larger precursor RNA that is capped and has a 3' poly(A) tail.
C) The precursor miRNA undergoes different types of post-transcriptional cleavage by endoribonucleases that are specific for double-stranded target sequences.
D) A nuclear endoribonuclease called dicer cleaves the miRNA precursor so that it forms a stem-loop RNA.

Question

Quizplus · Accepted Answer

MicroRNAs (miRNAs) typically bind to partially complementary sequences in the 3' untranslated regions (UTRs) of target mRNAs, leading to their degradation or inhibition of translation, not perfectly complementary sequences. Dicer is a cytoplasmic, not nuclear, endoribonuclease that cleaves precursor miRNAs into mature miRNAs.

With Respect to MicroRNAs, Which, If Any, of the Following