With respect to epimutations, which, if any, of the following statements, is false, from a practical viewpoint?
A) The term epimutation means an unexpected change in chromatin conformation, causing a gene to be expressed in an abnormal way that is not related to its base sequence.
B) A primary epimutation is a change in chromatin confirmation that is not related directly to any change in the base sequence.
C) A secondary epimutation arises from a standard mutation that results in a profound change of expression in a gene that regulates chromatin conformation.
D) A "chromatin disease" is a disorder that is consistently caused by a primary epimutation.

Question

Quizplus · Accepted Answer

From a practical viewpoint, all the other statements are true. However, a "chromatin disease" can be caused by various factors, not just primary epimutations. Chromatin diseases can also be caused by standard mutations, alterations in histone modifications or DNA methylation, nucleosome positioning, and other chromatin-related mechanisms.

With Respect to Epimutations, Which, If Any, of the Following