Question 1

Given a list of concordances (as percentages)for monozygotic and dizygotic twins for a selection of traits, describe how you would evaluate the relative input of environmental versus genetic factors for each trait.

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Question 2

A GWA study relies on the correlation between a QTL and a ________.

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Question 3

What is meant by a QTL?

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Question 4

Describe how quantitative traits can be explained in Mendelian terms.

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Question 5

Recent work in Drosophila demonstrated that the genes known as the chromatin remodeling complex co-localize at loci for hsp genes that respond to heat shock. Outline a procedure you could use to substantiate this finding.

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Question 6

Many human behavioral traits have both genetic and environmental components. Bipolar disorder has long been known to be familial, and more recently a number of genes and/or SNPs have been found to be involved. What are three or more reasons that this research has been hampered?

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Question 7

Distinguish between broad sense heritability and narrow sense heritability, and explain how either or both of these measures can be used to inform those using artificial selection.

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Quiz 21: Genetic Analysis of Quantitative Traits