Which of the following statements about hemoglobin is true? A) BPG decreases the affinity of hemoglobin for oxygen by stabilizing the T-state B) BPG decreases the affinity of hemoglobin for oxygen by releasing an H⁺ C) hemoglobin is composed of 4 myoglobin molecules D) hemoglobin binds carbon dioxide at the heme oxygen binding site E) increased acidity increases hemoglobin's oxygen affinity

Question

Quizplus · Accepted Answer

BPG (2,3-bisphosphoglycerate) binds to a specific site on hemoglobin and stabilizes the T-state conformation, which decreases the affinity of hemoglobin for oxygen. The T-state conformation has a lower affinity for oxygen than the R-state conformation, which is the relaxed state of hemoglobin in the presence of oxygen.

Which of the Following Statements About Hemoglobin Is True