In the typical globin protein, the conserved proximal histidine residue participates in the
A) binding of a proton as an allosteric effector.
B) coordination of the iron component of heme.
C) discrimination in binding between O2 and CO.
D) reversible formation of a carbamate.

Question

Quizplus · Accepted Answer

The conserved proximal histidine residue interacts with the iron component of heme and helps coordinate its binding to oxygen.

Answer: D
 The proximal histidine residue can form a reversible carbamate with CO2, which can affect oxygen affinity in the globin protein.

Therefore, the best choices are B and D.

In the Typical Globin Protein, the Conserved Proximal Histidine Residue