In the Holliday model for recombination, which is not true
A) one of two recombination products are formed depending on how the branch is cleaved
B) strand exchange leads to an intermediate structure with crossed single strands
C) two homologous duplexes are aligned
D) the branch can move along the strands leading to additional strand exchange
E) the strand exchange is initiated by DNase I nicking.

Question

Quizplus · Accepted Answer

The strand exchange is not initiated by DNase I nicking in the Holliday model, as this model proposes that the exchange is initiated by a double-strand break (DSB) in one of the homologous duplexes. The DNase I nicking is a different mechanism of recombination known as the single-strand annealing (SSA) pathway.

In the Holliday Model for Recombination, Which Is Not True