Cytotoxic T cells and NK cells kill by secretion of proteins.The first called perforin which forms complexes that penetrate the cell membrane and allows the passage of the apoptosis inducing protein granzyme to enter the targeted cell.

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Cytotoxic T cells and NK cells do indeed kill by secretion of proteins, including perforin and granzyme. Perforin forms complexes that penetrate the cell membrane, allowing granzyme to enter the targeted cell and induce apoptosis.

Cytotoxic T Cells and NK Cells Kill by Secretion of Proteins.The