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Biology
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Genetic Analysis
Quiz 21: Genetic Analysis of Quantitative Traits
Path 4
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Question 1
Multiple Choice
A group that is experimenting with selection in an insect species due to exposure to a newly developed insecticide,cpd AW143,has found that,after 10 generations of exposure,the population is now bimodal in its response to the drug.Close to 30% of the population are completely normal while 70% live only about 1/6 of the normal lifetime.This is an example of
Question 2
Multiple Choice
GWA looks at DNA marker distribution relative to that of supposed QTLs.Therefore,which of the following would be true of linkage disequilibrium?
Question 3
Multiple Choice
Alterations in the ratio of CD4:CD8 lymphocytes are associated with risk of HIV infection progressing to AIDS,of autoimmune diseases,and of progression of some cancers.In searching for predictors of these effects in normal individuals,researchers have found two independent QTLs in the region of the genome known as the major histocompatibility complex (MHC) ,one in a region regulating CD8 and the other in a region regulating CD4.What does this indicate for the general population?
Question 4
Multiple Choice
An increased number of patients have recently been diagnosed with celiac disease,which you may know of as gluten sensitivity (OMIM 212750) .It is a multifactorial disorder of the small intestine influenced by genes and environment,and it is characterized by malabsorption due to inflammation of the mucosa after eating wheat gluten or related proteins.It is now thought to occur in 1 out of 120 to 300 people.Genes found to be associated with it are in the HLA region of chromosome 6,namely DR3 and DQw2.Which of the following is more probable?
Question 5
Multiple Choice
It is estimated that 4.6% of SNPs and about 17% of all genes can be defined as pleiotropic.Which of the following might be a significant lesson for a consumer of genetic information based on this finding?