As the level of visceral fat increases there is a concomitant loss of peripheral tissue responses to insulin. Adipose tissue responses to these metabolic changes include a reduced secretion of which of the following adipokines?
A) adiponectin
B) adipsin
C) IL-6
D) leptin
E) resistin

Question

Quizplus · Accepted Answer

Adiponectin is an adipokine that enhances insulin sensitivity. As visceral fat increases, adiponectin secretion decreases, contributing to insulin resistance.  Expression and release of adiponectin is stimulated by insulin, therefore adiponectin levels are reduced in obese individuals primarily due to the loss of insulin-mediated stimulation. In patients with Type 2 diabetes, levels of adiponectin are also significantly reduced.

As the Level of Visceral Fat Increases There Is a Concomitant