During an experiment on hemoglobin function, knockout mice that are unable to synthesize globin proteins are created. Absence of which of the following globin proteins is most likely to be incompatible with life in these mice?
A) a
B) b
C) δ
D) g

Question

Quizplus · Accepted Answer

a-globin is essential for the formation of hemoglobin A, the major oxygen-carrying protein in red blood cells. Without a-globin, mice would not be able to transport oxygen effectively and would likely die shortly after birth.  The a-thalassemias result when there is reduced expression at one or both of the a-globin genes. In the a-thalassemias normal amounts of b-globin are made. Theb-globin proteins are capable of forming homotetramers (b4), and these tetramers are called hemoglobin H (HbH). An excess of HbH in red blood cells leads to the formation of inclusion bodies commonly seen in patients with a-thalassemia. In addition, the HbH tetramers have a markedly reduced oxygen-carrying capacity. High level of HbH results in the disorder known as HbH disease.

During an Experiment on Hemoglobin Function, Knockout Mice That Are