Using Cre recombination, the gene encoding stem cell factor (SCF) can be deleted in specific cell types in adult mice. Deletion of this gene in which of the following cells would you expect to lead to the most significant depletion of hematopoietic stem cells in the bone marrow?
A) Osteoblasts
B) Osteoclasts
C) Stromal cells
D) Hematopoietic stem cells
E) Common myeloid precursor cells

Question

Quizplus · Accepted Answer

Stem cell factor helps define the stem-cell niche in the bone marrow stroma. It binds to Kit, a receptor tyrosine kinase, on the surface of hematopoietic stem cells to maintain their stem-cell state. Note that in mice, spleen and liver can also be home to hematopoietic stem cells.

Using Cre Recombination, the Gene Encoding Stem Cell Factor (SCF)