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Biochemistry 6th Edition by Reginald Garrett,Charles Grisham
Edition 6ISBN: 978-1305577206Biochemistry 6th Edition by Reginald Garrett,Charles Grisham
Edition 6ISBN: 978-1305577206 Exercise 15
Energetics of 1,3-bisphophoglycerate hydrolysis
(Integrates with Chapter 3.) The standard free energy change (?G°') for hydrolysis of 1,3- bisphosphoglycerate (1,3-BPG) to 3-phosphoglycerate (3-PG) and Pi is -49.6 kJ/mol:
1,3-BPG + H2O ?? 3-PG + Pi
The standard free energy change (?G°') for ATP hydrolysis is -30.5 kJ/mol:
ATP + H2O ?? ADP + Pi
a. What is the standard free energy change for the phosphoglycerate kinase reaction:
ADP + 1,3-BPG ?? ATP + 3-PG
b. What is the equilibrium constant for this reaction?
c. If the steady-state concentrations of [1,3-BPG] and [3-PG] in an erythrocyte are 1 µM and 129 µM, respectively, what will be the ratio of [ATP]/[ADP], assuming the phosphoglycerate kinase reaction is at equilibrium?
(Integrates with Chapter 3.) The standard free energy change (?G°') for hydrolysis of 1,3- bisphosphoglycerate (1,3-BPG) to 3-phosphoglycerate (3-PG) and Pi is -49.6 kJ/mol:
1,3-BPG + H2O ?? 3-PG + Pi
The standard free energy change (?G°') for ATP hydrolysis is -30.5 kJ/mol:
ATP + H2O ?? ADP + Pi
a. What is the standard free energy change for the phosphoglycerate kinase reaction:
ADP + 1,3-BPG ?? ATP + 3-PG
b. What is the equilibrium constant for this reaction?
c. If the steady-state concentrations of [1,3-BPG] and [3-PG] in an erythrocyte are 1 µM and 129 µM, respectively, what will be the ratio of [ATP]/[ADP], assuming the phosphoglycerate kinase reaction is at equilibrium?
Explanation
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a. The reaction of
is the sum of two ...
Biochemistry 6th Edition by Reginald Garrett,Charles Grisham
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