Urinalysis and Body Fluids 6th Edition by Majorie DiLorenzo, Susan Strasinger

Exercise 52

The finding of oligoclonal bands in the CSF and not inthe serum is seen with:

A. Multiple myeloma

B. CNS malignancy

C. Multiple sclerosis

D. Viral infections

Step 1 of 2

Oligoclonal bands:

Oligoclonal bands are proteins named immunoglobulins that indicate inflammation within central nervous system.

• It is also indicative of multiple sclerosis

• Oligoclonal bands are detected through electrophoresis

• The bands in gamma region of protein electrophoresis indicates production of immunoglobulin

• Presence of more than two oligoclonal bands in CSF, which is not present in serum is valuable to diagnose multiple sclerosis

• Oligoclonal bands will be positive during multiple sclerosis remission and disappears in other disorders

Therefore, oligoclonal bands findings in CSF and not in serum is found in “multiple sclerosis”. Hence, the correct answer is option.