Urinalysis and Body Fluids 6th Edition by Majorie DiLorenzo, Susan Strasinger

Exercise 49

The integrity of the blood–brain barrier is measured using the:

A. CSF/serum albumin index

B. CSF/serum globulin ratio

C. CSF albumin index

D. CSF IgG index

Step 1 of 2

Blood-brain barrier:

• Choroid plexus have endothelial cells that consists of tight-fitting junctures

• These junctures are called blood-brain barrier, which do not allow passage of many molecules

• This barrier also prevents passage of medications and antibodies

• Blood-brain barrier integrity should be maintained to protect brain from chemical substances present in circulating blood

• Blood-brain barrier is calculated using the formula CSF (cerebrospinal fluid)/serum albumin index

• Serum albumin index of CSF is evaluated after determining CSF albumin concentration in mg/dL (milligrams per deciliter) and serum concentration is denoted in g/dL (grams per deciliter)

Therefore, integrity of blood-brain barrier is measured with “CSF/serum albumin index”. Hence, the correct answer is option.