Urinalysis and Body Fluids 6th Edition by Majorie DiLorenzo, Susan Strasinger

Exercise 34

A teenage boy who develops gout in his big toe and has a high serum uric acid should be monitored for:

A. Fanconi syndrome

B. Renal calculi

C. Uromodulin-associated kidney disease

D. Chronic interstitial nephritis

Step 1 of 2

Uromodulin-associated kidney disease:

Inherited disorder caused by autosomal mutation producing abnormal uromodulin.

• Mutation causes lesser uromodulin production and it is replaced by abnormal uromodulin.

• Abnormal uromodulin is produced by tubular cells and accumulates there itself destroying the tubular cells causing renal transplantation.

• The mutation causes increase of uric acid in serum which results in persons developing gout in the teenage years before renal disease detected.

Gout:

• Defective metabolism of uric acid which causes arthritis in smaller bones of feet often near the base of big toe.

Therefore, a teenage boy with gout in big toe and high serum uric acid is monitored for “uromodulin-associated kidney disease”. Hence, the correct answer is option .