Urinalysis and Body Fluids 6th Edition by Majorie DiLorenzo, Susan Strasinger

Exercise 40

Describe the relationship of urinary bilirubin and urobilinogen to the diagnosis of bile duct obstruction, liver disease, and hemolytic disorders.

Step 1 of 2

Relationship of urinary bilirubin in bile duct obstruction, hemolytic disorders and

liver disease:

The conjugated bilirubin only occurs in urine when degradation phase is disturbed due to bile duct obstruction (post hepatic jaundice).

• Cancer or gall stones or liver integrity damage permits conjugated bilirubin to move in the circulation

• Absence or presence of urinary bilirubin helps to identify clinical jaundice

• Urine bilirubin shows positive result to bile duct obstruction

• Liver is damaged by hepatitis or cirrhosis condition

• Urinary bilirubin provides early indication of liver disease. Urine bilirubin may show +ve or -ve result for liver damage

• Negative result is seen in urine bilirubin for hemolytic disease