An early step in shotgun sequencing is to ________.
A) break genomic DNA at random sites
B) map the position of cloned DNA fragments
C) randomly select DNA primers and hybridize these to random positions of chromosomes in preparation for sequencing
D) separate molecules of DNA according to size in an electric field

Question

Quizplus · Accepted Answer

Shotgun sequencing involves breaking genomic DNA at random sites, which generates a pool of smaller fragments that can then be sequenced and assembled into a full genome sequence.

An Early Step in Shotgun Sequencing Is to ________