Quiz 59: Pharmacotherapy of Peptic Ulcer Disease


Gastro esophageal reflux disorder (GERD) is a physiological abnormality in which the acidic contents of stomach reflex into esophagus. The causes of GERD include weakened lower esophageal sphincter, impaired acid clearance in the stomach due to unhealthy food habits and pregnancy, infection with H.pylori and stress. Heart burn and acid indigestion are the common symptoms of GERD. Taking OTC (over the counter) drugs or GERD is not suggested because, • The underlying cause will be left untreated and the symptoms may become worsen with time. • Regular intake of antacids causes decreased absorption of certain vitamins and minerals such as vitamin B12, iron, calcium, etc. • Calcium malabsorption causes weakened skeletal system and increase the risk of fractures. • Decreased gastric acid secretion causes increased risk of infections.

Doxorubicin is an anthracyclin antibiotic used in the treatment of cancer. It acts by intercalating DNA and is used in the combination therapy of a wide range of cancers including the hematomas and solid tumours. Streptozocin is an alkylating agent, which is used in cancer chemotherapy. It is commonly used in the treatment of tumours of islet cells of pancreas and carcinoid tumours.

Peptic ulcer disease (PUD) is a lesion of the mucosal layer n the stomach or duodenum that may be caused by pathogenic bacteria or pepsin and other gastric acids. The most common causes of peptic ulcers include the infection caused by the bacterium Helicobacter pylori or H. Pylori, medications that disturb the gastric mucosa, psychological pressures and irregular food habits that result in improper acid secretions that damages gastric mucosa. The risk factors for PUD in Hugh include the following: • Smoking increases the risk of infection from Helicobacter pylori. • Regular usage of ibuprofen (non-steroidal anti-inflammatory drug) • Infection with H.pylori

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