Quiz 52: Pharmacotherapy of Fungal Infections


Sepsis is a life threatening condition, characterized by the symptoms including fever, palpitations, increased rate of respiration and confusion. Sepsis is also known as "blood infection" because, the organism enters into the systemic circulation. Immune compromised people are at more risk of developing sepsis, but all people may develop sepsis. People receiving chemotherapy suffer from decreased immune functioning, so they are at higher risk of developing opportunistic infections caused by fungus and bacteria. The patient is given IV antibiotics because the infection is spread to the systemic circulation, and there is also a risk of developing fungal infections.

The following classes of drugs act by inhibiting the cell wall synthesis (inhibitions of peptidoglycan later formation) in bacteria: • Penicillins • Cephalosporins • Carbapenems • Monobactams • Glycopeptide antibiotics such as vancomycin These drugs are not effective against the fungus because the fungal cell wall do not contain the peptidoglycan layer, they contain "chitin, ergosterol and glucans" in their cell wall.

Oropharyngeal candidiasis is otherwise known as "thrush," in which the fungal infection occurs in the mucous layers of mouth and pharynx. The important sign of oropharyngeal candidiasis is, the occurrence of white patches over the oral mucous membranes and on the tongue. These white patches or plaques indicates the fungal growth. The patient suffers from difficulty in swallowing due to the soreness.

Related Quizzes