Quiz 50: Sulfonamides and the Pharmacotherapy of Urinary Tract Infections


Using urinary catheters as a solution for urinary incontinence is not advised because the underlying cause is different and it progresses if left untreated. The urinary incontinence may be due to urinary tract infections, bladder cancer, stress, inflammation of bladder, nerve or spinal cord injury, CNS problems and bladder stones. The following are the complications of using urinary catheters: • Chances of occurrence and progression of bacterial infections • Allergy to the catheter material • Kidney damage with long term usage • Injury to the urethra • Appearance of blood in urine • Bladder stones

Fluoroquinolones are the broad spectrum antibiotics that act by causing the double stranded breaks in DNA, which kills the cells. They are mostly used for the treatment of urinary tract and respiratory tract infections and also against resistant bacterial strains. The black box warning accompanied with the oral and parental fluoroquinolones indicates their adverse effect of causing "tendo n rupture."

As the patient is suffering from the recurrent urinary tract infections (UTIs), there is a need to explain how the recurrence of infections occur. It is also important to provide the information regarding the usage of antibiotics and maintaining personal hygiene. It is given that the patient did not use her complete course of prescription, which is the main cause of recurrence. It is important to complete the total course of prescribed antibiotics though the symptoms disappear. This is because the bacteria or other microbes remain dormant and can become active under favourable conditions. These recurrent strains may become resistant against the previous antibiotics what we used and no longer respond to the same therapy again. Thus, the patient must be instructed to complete the total course of antibiotics without missing a single dose. Maintaining personal hygiene is also important to avoid the urinary tract infections.

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