Pharmacology Study Set 4
Quiz 42 :
Immunostimulants and Immunosuppressants
Cyclosporine is an immunosuppressant which is being administered to Gordan after his kidney transplantation. The drug inhibits the calcineurin receptors and thus, the activation of T-cells and B-cells is inhibited. The calcineurin receptors are preferred as immunosuppressant to prevent the transplant rejection. Hence, it gets clear that due to the kidney transplantation in Gordan, he is receiving cyclosporine to prevent the transplant rejection by his immune system.
Neumega (Oprelvekin) is the immune-stimulant drug which is primarily indicated when the platelet count of the patient is decreased. This drug stimulates the platelet production in the body of the patient. The common adverse effects with Neumega are atrial fibrillation, syncope, dyspnea etcetera. When such effects are observed then the dosage is reduced after consultation with the physician or the drug may be discontinued in severe cases.
In the case of Carol, the cells of her liver have been damaged due to her being alcohol abuse in her past. Now, her immune system has got weak and made her liver prone to the damage. This has led her to deal with a deadly disease named Hepatitis C. The rationale behind administering INF (Interferon) alfa 2b to Carol is to stimulate her body's immune system. Her body's immunity has got weak due to liver damage and thus, the drug will stimulate her immune system and prevent the further damage to her liver tissues.