Quiz 46: Immunopharmacology

Nursing

Immunosuppressive drugs are referred to as the drugs that have an ability to suppress the immune response of the body. It is desirable to suppress the immune function of a person's body when being treated for severe allergic reactions. This is also important when the treatment of person is being done for immune-based diseases. The examples of such disorders include multiple sclerosis, myasthenia gravis, and systemic lupus erythematous. The suppression of immune function is important for preventing rejection of organ like organ transplantation. This is because if it is not suppressed then immune system might get activated in an unusual manner that can destroy the person's body as well as chances of transplanted organ being rejected increases.

a. The drug Cyclosporine is an example of immunosuppressive drug. It is a polypeptide metabolite and is not cytotoxic in nature. The mechanism of cyclosporine involves T-helper cells so the immune response is reduced to a significant level. b. The major issue in the use of drug cyclosporine is in the development of nephrotoxicity that is characterized by damage caused to renal tubules. The other effects like liver toxicity and disturbances like paraesthesias and seizures occur at a lesser rate. c. Often these are used in combination with other chemotherapeutic agents for inhibiting the proliferation of cancerous cells. This enzyme is found to be associated with epidermal growth factor receptors. The major use of this drug is to prevent organ rejection after transplantation.

When a foreign particle enters the host body the antigen presenting cells recognize the particle. This is recognized by Th cells which activate the killer t cells and B cells. Option A) Th cells activates macrophage. However, macrophage does not activate killer cells. Therefore, this is not the correct option. Option B) activation of B cell leads to antibodies production in the cell. Therefore, this is not the correct option. Option D) activation of killer t cells does not activate the B cells. Therefore, it is not the correct option. Option E) memory t cell are activation in the secondary response. Therefore, it is not the correct option. Since, the activation of helper T cell with the help of CD4+ recognizes the pathogen. This leads to activation of killer t cell and B cell. Therefore, the correct option is img .

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