Quiz 29: Antianemic

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A balanced diet includes carbohydrates, proteins and lipids. Lipids are essential to the body for various functions such as formation cell membranes, nerve tissue and plasma lipoproteins. Essential dietary lipids are fatty acids, triglycerides and cholesterol. When excess lipids are consumed they are stored in adipose tissue as the reserve source of energy. Excess fatty acids consumption results into deposition of fatty acids on the blood vessels lining which will affect the blood circulation. In such case, hypolipidemic drugs play important role by lowering the amount of lipids in the body by various mechanism. For day-to-day activity body needs cholesterol which is secreted and stored in gallbladder. It is the fundamental building block for various steroid hormones. It is the component of bile salts required for the dietary fat digestion in the body. Body maintains the homeostasis of cholesterol storage and production. Lipids are essential in body but high levels of lipids are correlated with the several adverse effects and disorders. When excess lipids are consumed they are stored in adipose tissue as reserve source of energy. Excess fatty acids consumption results into deposition of fatty acids on the blood vessels lining which will affect the blood circulation is known as hyper-lipidemia. It leads to cause diabetes mellitus, lupus erythematosus, lipodystrophies, hypothyroidism and premature atherosclerosis.

Lipids are essential in the body but high levels of lipids are correlated with the several adverse effects and disorders. When excess lipids are consumed they are stored in adipose tissue as the reserve source of energy. Excess fatty acids consumption results into deposition of fatty acids on the blood vessels lining which will affect the blood circulation is known as hyper-lipidemia. It is characterized by the elevated levels of lipids in plasma and treated with hypolipidemic drugs to lower the lipid level. The clinical strategy behind these hypolipidemic drug is to lower the level of bad cholesterol i.e. LDL (low density lipoprotein) by reducing the serum cholesterol and triglycerides. These drugs also help to raise the level of good cholesterol i.e. HDL (high density lipoprotein) as high as possible. There are five different types of hypolipidemic drugs that are used in treatment of hyper-lipidemia. They are used for management of the disease, prevention of severe disease such as coronary events and for slow progression of atherosclerosis. Out of the five groups of hypolipidemic drugs HMG-CoA (3-hydroxy-3-methyl-glutaryl-CoA) reductase inhibitors (statin) are commonly used. Lovastatin was the first novel drug used to alter the cholesterol synthesis in liver. They work by inhibiting the enzyme HMG-CoA reductase. (Lovastatin)Statins inhibit the enzyme HMG-CoA reductase and thus limit the production of mevalonic acid. Lovastatin reduce the LDL, VLDL (very low density lipoprotein) and triglycerides level along with raising the HDL level in plasma. There are certain adverse effects related to the use of statins such as headache, dizziness, insomnia, flatulence, cramps in abdomen and photosensitivity. Some people also experience memory loss along with the lack of concentration. Sometimes muscle pain and weakness can be observed. It is recommended to test liver function before treatment initiation with statins. Liver function test confirms the status of (ALT) alanine aminotransferase and (AST) aspartate aminotransferase in the patient. These are the liver enzymes that helps in conversion of protein to energy. When the liver or muscle gets damaged the level of ALT and AST increases in blood. Statins can raise the level of liver enzymes and need chronic therapy to return the level to normal. It is recommended to check the ALT and AST level in liver after every 6 to 12 weeks.

75 To 80 percent of complete cholesterol in the body doesn't enter the body as dietary cholesterol, doesn't move as chylomicrons in the blood, doesn't ship as HDL, and doesn't cause hyperlipidemia.. Hence, the options (B), (C), (D), and (E) are incorrect. Cholesterol is also required to form vitamin D, hormones (including androgen and estrogen), and fat-dissolving digestive juice acids. sterol production is therefore necessary that your liver and intestines create concerning eightieth of the sterol you would like to remain healthy. solely concerning 2 hundredth comes from the foods you eat. Hence, the correct answer is option img

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