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Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
Edition 11ISBN: 9781292139456Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
Edition 11ISBN: 9781292139456 Exercise 23
Host transgenic mammals are often made by injecting transgenic DNA into a pronucleus, a process that is laborious, technically demanding, and typified by yields of less than 1 percent. Lately, the engineered lentivirus, a retrovirus, has been used to generate transgenic pigs, rats, mice, and cattle with greater than 10 percent efficiency (Whitelaw, 2004). Lentivectors have reverse transcriptase activity, can infect both dividing and nondividing cells, and are replication-defective. Present, in a labeled diagram, a strategy for producing a transgenic mammal carrying a pharmaceutically important gene using a lentivector.
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Basically, this is gene "pharm...
Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
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