
Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
Edition 11ISBN: 9781292139456
Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
Edition 11ISBN: 9781292139456 Exercise 26
Traditionally, gene sequence homology implied functional similarity. Even though two proteins may contain over 60 percent sequence identity, only about 38 percent have identical functions (Roy et al., 2008). In some cases, closely related homologs may engender completely different classes of proteins (enzymes). Consider the 3D structure of two proteins with 60 percent homology with entirely different functions. Explain how different functions may evolve by discussing the position of the homologous amino acid track, its relation to nonhomologous tracks, and the role that chaperones may play in determining protein function.
Explanation
Gene sequence homology can imply functio...
Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
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