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Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
Edition 11ISBN: 9781292139456Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
Edition 11ISBN: 9781292139456 Exercise 31
Klemke et al. (2001) discovered an interesting coding phenomenon in which an exon within a neurologic hormone receptor gene in mammals appears to produce two different protein entities (XL ? s, ALEX). Following is the DNA sequence of the exon's 5? end derived from a rat. The lowercase letters represent the initial coding portion for the XL ? s protein, and the uppercase letters indicate the portion where the ALEX entity is initiated. (For simplicity, and to correspond with the RNA coding dictionary, it is customary to represent the noncoding, nontemplate strand of the DNA segment.)5?-gtcccaaccatgcccaccgatcttccgcctgcttctgaagATGCGGGCCCAG
(a) Convert the noncoding DNA sequence to the coding RNA sequence.
(b) Locate the initiator codon within the XL ? s segment.
(c) Locate the initiator codon within the ALEX segment. Are the two initiator codons in frame?
(d) Provide the amino acid sequence for each coding sequence. In the region of overlap, are the two amino acid sequences the same?
(e) Are there any evolutionary advantages to having the same DNA sequence code for two protein products? Are there any disadvantages?
(a) Convert the noncoding DNA sequence to the coding RNA sequence.
(b) Locate the initiator codon within the XL ? s segment.
(c) Locate the initiator codon within the ALEX segment. Are the two initiator codons in frame?
(d) Provide the amino acid sequence for each coding sequence. In the region of overlap, are the two amino acid sequences the same?
(e) Are there any evolutionary advantages to having the same DNA sequence code for two protein products? Are there any disadvantages?
Explanation
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Verified
(a) Since, the non-template DNA strand i...
Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
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