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Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
Edition 11ISBN: 9781292139456Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
Edition 11ISBN: 9781292139456 Exercise 43
Proto-oncogenes stimulate cells to progress through the cell cycle and begin mitosis. In cells that stop dividing, transcription of proto-oncogenes is inhibited by regulatory molecules. As is typical of all genes, proto-oncogenes contain a regulatory DNA region followed by a coding DNA region that specifies the amino acid sequence of the gene product. Consider two types of mutation in a proto-oncogene, one in the regulatory region that eliminates transcriptional control and the other in the coding region that renders the gene product inactive. Characterize both of these mutant alleles as either gain-of-function or loss-of-function mutations and indicate whether each would be dominant or recessive.
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Loss-of-function mutation reduces or eli...
Concepts of Genetics 11th Edition by William Klug,Michael Cummings,Charlotte Spencer,Michael Palladino
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