Which of the following substituted cyclohexanes has the most negative value of ΔG° for ring flipping from the conformation in which the substituent is axial to the one where it is equatorial?
A) fluorocyclohexane
B) methylcyclohexane
C) ethylcyclohexane
D) tert-butylcyclohexane

Question

Quizplus · Accepted Answer

Tert-butylcyclohexane has the most negative ΔG° for ring flipping because the tert-butyl group is much larger and more sterically hindered than the other substituents listed. This causes a significant increase in steric strain when the tert-butyl group is in the axial position compared to the equatorial position, making the equatorial conformation much more stable and favored.

Which of the Following Substituted Cyclohexanes Has the Most Negative